The Relationship between Genetics and Pain

Dr. Joe Tatta:                Dr. Susanne Bennett is an internationally recognized integrative functional medicine expert with over 27 years of clinical experience in the fields of allergies, clinical nutrition, methyl genetics, and anti-aging medicine. She’s the author of the international bestseller mighty Mito as well as the Seven-day Allergy Makeover. She’s also the talk show host of wellness for life on radio MD and iHeartRadio and is devoted to sharing the best health strategies and providing easy to implement tips to improve your life and start feeling better today. You know, all-natural way. Dr. Susanne is also the CEO and founder of pure Regenix, a skincare company dedicated to creating noninvasive products and cutting edge formulations to help prevent premature skin aging, rejuvenation, and restore optimal skin health. Dr. Susanne Bennett, welcome back to the Healing Pain Summit. It’s great to have you here again.

https://youtu.be/d0NWlmEZS5c

Dr. Bennett:                  Oh Joe, thanks so much. Thanks so much for inviting me. I’m excited that I’m here on the second year. Congrats to this pain summit. It’s very exciting time. I’m excited to share my new information.

Dr. Joe Tatta:                Thank you. And you know, there, there are so many ways that we can get out of pain. And you know, we’re starting to learn a lot about genetics and methylation and things of that nature. And it’s a, it’s a really fast-growing topic, but I know you’ve been involved in this for years, so I’d be really excited to talk to you. So I think a good place to start is just to ask first, what is methylation?

Dr. Bennett:                  Okay, so the word methylation is a big word Joe, but I’m going to make it as easy as I can. And I, I thought about how am I going to present this because it’s a lot of biochemistry. I decided to do some show on tech. You’re going to be seeing and everyone out there are going to be seeing all kinds of little pictures and I want to make sure that I got this right. Joe, can you see, can you read that?

Dr. Joe Tatta:                I can’t. I can see a, um, you know, I see a lot of, you know, those are chemical reactions and I see one that has a blue circle around it.

Dr. Bennett:                  Yeah, yeah, yeah, that’s right. So what this is right here is actually part of your methylation. All right? That’s that little part out of billions of chemistry, chemical reactions. I mean in every second in our body, every second we’ve got all of these chemical pathways going on. So it’s super important that it’s just one little part of what’s going on in our beautiful body. But it’s a very important part. And when you think about what methylation really means, what basically it means is that it takes a three carbon, a three, excuse me, one carbon with three hydrogen atoms, and they create what’s called a methyl group. This methyl group is called C H three can you see that?

Dr. Joe Tatta:                Yup. That’s, that’s a slide two of the show and touch. I love show and tell by the way. This is awesome.

Dr. Bennett:                  Yes. So what, when you’re doing a basic, you know, basic sets, we’re actually combining and methylation, that methyl group to another. So let’s say this is a molecule and you’re adding the methyl group, and then when you add this, it becomes a new molecule with a methyl attached to it. And what that looks like, I’ll show you is something, let’s say like this. You don’t need to know anything, but do you see that little ch three? Yep. See that there? So that’s a methyl group, right? Yep. That’s a methyl group. And we attached it. And right now when you think about it, there’s an enzyme that makes that work. So one of the things that people don’t know much about is even the word enzyme, it’s very difficult to understand. So let me just give you a little bit of what enzyme means. All right?

Dr. Bennett:                  So it’s, they’re basically molecules or protein type of molecules that’s produced by your genes. Actually, your genes make enzymes and these enzymes are important because they actually turbocharge the reaction. So for instance, I’m just giving you another example, red plus blue molecule, and it, let’s say a magenta, but for this whole process to occur, you need an enzyme, all right? And now it’s not just adding two molecules together. You can actually go backwards. I should say. I should’ve put an arrow the other way because there are other enzymes that break down a big molecule into two smaller ones, let’s say. All right. A very common molecule that we talk about, I used to say an enzyme that we talk a lot about in methylation, at least in metal genetics, is what’s called a GAD enzymes called glutamate decarboxylase, and what it does is it takes blue to mate and changes into Gabba, Gabba very, very important molecule for brain, but those are the things that we need and we also need to look at these enzymes because why do we want these enzymes to occur optimally?

Dr. Bennett:                  Because it makes all the reactions go really well now smoothly. Now genes, like I said, genes are made out of enzymes. You’ve heard of the GAD right here, but there’s a lot of other really important enzyme in the methylation process. One’s called MTHFR that a lot of people ask about. There is the VDR, there’s the COMT, the Mao, a M T army. I can go on and on, but I’m going to show you where these all of these ends up. This is right now the methylation process. I know it’s, it’s kind of a, you know, it’s a lot of chemistry here, but what I want you to know is this whole process is run by enzymes. So if you look here is the MTR. Uh, right here is the MTHFR, right? There’s a matching there. There’s a CBS gene here. Um, so there’s all of these genes and your genes are made out of your, excuse me, your enzymes are made out of your genes.

Dr. Bennett:                  Now, once you understand that those genes, those enzymes are super important in to your methylation process, then you’ll know that if you’ve got these genetic variants that we are all born with, I mean, we all have inherited things from our parents, right? We might have allergies, let’s say we might have a predisposition to sugar imbalances, diabetes, cancers, even Alzheimer’s, and we’re, we’re constantly afraid of that kind of stuff. But once you understand these genes, these genes can actually be manipulate it. You’re going to be able to change the actual future and the way they’re expressed, which is called the phenotype. You might have a whole slew of people in your, your family that have all of these weaknesses and these imperfections that I call. But even though you might have that, it doesn’t mean that you’re going to go that same route. So that’s what I want people to understand is methylation is a, is a big term, but what it means is that we can use the most, it’s the most studied pathway I believe of considered what’s called epigenetic pathway, epigenetic variants.

Dr. Bennett:                  What that means is things that are, that affect our body from our environment, things that we eat, all of this stuff. It’s the most most studied pathway in the body. So it, you know, I want to be able to tell you that your, your destiny is not due to your genes, your, you can change them. Joe, you didn’t change them and you say, I know that’s such a new area of science that slowly is working its way into medicine, non mainstream medicine. Unfortunate but it’s definitely working its way into functional medicine, integrative medicine, alternative medicine. But let’s get back to some of those pathways. Cause I love bio chemistry. I’ve taken tons of chemistry courses, but what are some of the more vital cellular functions that are involved in this mess methylation pathway in this methylation process? Yeah, so very important to understand why, why do we need them and why is methylation so important?

Dr. Bennett:                  Because they actually help. Here’s another one really important for processing and detoxification of your chemicals so you could see that, right? Detoxification. Number two, it’s really important for gene regulation. You want to regulate your genes, you want to turn them on, you want to turn them up. There’s, you know, methylation is almost like these on and off switches that are going off all throughout your body, but you want to switch them on properly, right? We don’t want the bad ones going on. We want the good ones going on and we want to tone down and slow down the bad, bad genes of regulation and what’s next. It actually helps fight your infections, fight infections, your T cells, your natural killer cells, really important to be able to upregulate them. So the building blocks of that comes from methylation. It’s also super important that they’re studying, that methylation is really poor for autoimmune disease and so it affects your immune factors and how it’s regulated.

Dr. Bennett:                  Then what’s more than is what else breaking down of hormones. So if you can detox your hormones properly, let’s talk about estrogen. A lot of people, you know, in America we have trouble with estrogen dominance and it’s something that you can be tested for and all that, but it’s important that your detoxification pathways that’s related to methylation is working because if it’s not working and there’s one, a marker called a COMT, uh, it’s a gene that you want to make sure that’s working properly. If that’s not working well, and you’re going to have things like PMs symptoms, right? Um, COMT is also very important for your brain, a function of dopamine. So if you’ve got, if you don’t have enough cot working properly, you can’t break it down. Those neurotransmitters, which I’m just going to tell you right now, it’s very important for neurotransmitter production or I should have production and breakdown, then you’re going to have symptomatology in your emotional state.

Dr. Bennett:                  You’re not going to be able to think properly. People have trouble with focusing. Some people have over, in fact, this is a COMT is really important for pain control. You can have a great deal of pain issues. All right, so what’s next? It actually helps, helps with production of antioxidants, antioxidants and repairing your DNA. Super important that we want to be able to repair DNA because if you can’t then you’re all, you’re going to start having more diseases in the future cause then you’re obviously you’re aging faster, right? We all know that if you can’t repair your tissues, you can’t age faster. So then, well, let’s look at my favorite, one of my favorite subjects, which is energy production, energy production. You want methylation to occur properly because it actually helps with cocuten production, carnitine production. These are all enzymes that our body makes, these antioxidants and nutrients that will help us with energy production and of course 80 preproduction, which is what your energy is.

Dr. Bennett:                  Then what’s next? Building neurotransmitters. I already told you that dopamine, serotonin, and then I did tell you about even Gabba a little earlier and we also want to be able to break down our transmitters. We also want to make sure that you understand that methylation is important for building your myelin myelin sheath. The myelin sheath is not something that a lot of people talk about, but it’s really well known in the neurological disease world. Multiple sclerosis, Lou Gehrig’s, Lou Gehrig’s disease, you know, which is like a Milo trophic, lateral sclerosis, that kind of stuff. So it’s important that we know for our nerves to be healthy. You know, if you ended up getting tingling in your fingers and your hands, um, a lot of pain syndromes like your feet, you’re burning thing that might be due to myelin issues and you’re not able to produce enough myelin.

Dr. Bennett:                  So methylation enzymes are very important for that. What else? Building blocks of your cell membrane and particularly in the foster title, coli phosphatidylcholine is one of those ingredients that are made also in our body. And um, there’s um, it’s an enzyme called P E M T. super important. But if you can’t make that enzyme right, you can’t make the fuss metallic calling within your own body, then you have trouble with this fossil lipid in creating those cell membrane by lipid membrane, which is so important for communication from the outside to the inside of the cell, for you to be able to bring in nutrients into the cell and get all the toxins out. You need a healthy cellular membrane and that’s for every cell in your body and foster title. Coleen is super important for that. And then the last is your DNA and histone synthesis. Now what are his stones? These are proteins that actually wrap around the DNA and it protects, it, protects it and keeps it in shape. So you know what, as you can see, there’s a ton of reasons why you need to have healthy methylation process.

Dr. Joe Tatta:                Yeah, I mean those are the, obviously there are hundreds of thousands of reactions and you gave us, you know, a really good snapshot of some of the more important ones. But so this is a paint summit. Obviously people won’t be in the most interested in learning about what their pain is caused by how they can alleviate it. So are there one or two from those specific cards that relate directly to painters? There’s something very specific that we should be aware of when it comes to pain.

Dr. Bennett:                  Well, let me tell you, I mean pain, obviously it’s the a hundred over a hundred thousand people, right? You know the stats on this, we are all suffering from pain and it can be acute pain. Obviously when you get injured, let’s say, and your body gives you pain for a reason. So to me, acute pain is super, super important. But I’ll tell you what, it’s more of the chronic thing. So if you’re out there right now suffering from pain and you want to get rid of pain, what you need to know is that you need more oxygen to that area and blood flow to that area too, to get rid of your pain. You also want to be able to increase the ability to eliminate all those metabolic end products such as free radicals from the damage, right? And lactic acid buildup in that area. You need that to happen.

Dr. Bennett:                  You also need to open up those areas that you might actually be, have toxins and those toxins need to be flushed out the chemicals that you might have absorbed that needs to be flushed out. That causes me, that’s really important. You’ll also want to reduce the excess amounts of inflammatory chemicals. There are natural, but you need to get that out to reduce pain. You’ll also, gosh, inflammation, those damaged tissues and, and you need to be able to heal them. That is the part that’s very important to get rid of pain. And then of course, you know when you need, you need those optimal neurotransmitters. You need energy that Hep from those mighty, mighty, Midas, the mitochondria. So all of these things that I just talked about are related to pain control, mitigating pain. So it’s important that methylation, every one of those areas, I just said you, if you want to get rid of paint, you need to know your methylation pathways. You need to know where are they blocked, what, where are the slow slowing down? And, and that’s super important. So that you can live the most pain free life as we can. That’s what I want. I don’t want to live with pain.

Dr. Joe Tatta:                No, me neither. I want to live a painless life and I want to in a very active life. Um, yeah. You know, as you’re talking, I’m sitting here and I’m wondering how did you, how did you get started? How did you get interested in dealing with methylation and the pathways and learning about it and using it to practice?

Dr. Bennett:                  Yes. You know, methylation has been more of the M in a more recently, people are talking more about methylation, but I’ve actually, it was 2011 and you know, thousand 2005 11 years ago, sorry, 2005 11 years ago when I first went to my first seminar methylation, that was from dr Amy Jasko and at the time I had a lot of Lyme disease cases and autism cases and any ESCO was the big gal who knew how to work with autistic children. So she had her first conference and I was able to go there. I was so happy and learn everything from her back then. She also wrote this book called genetic bypass and it was, back then, you could see it here. It was, you can see I did a lot of studying, a lot of that. This was the Bible of domain on methylation because nobody ever really wrote about it.

Dr. Bennett:                  That correlated with this clinical picture, you know, the physical body, the human body, and how it was manifesting. All of these methylation issues was manifesting. And what she found out was with, with these young people who had autistic tendencies in that spectrum of autism, they had very interesting, typical genetic variant issues. So I learned all about them, but there was a big problem back then, you know, um, 2005, there weren’t any major tests that you can do. There were tests to get, get your, to learn about your methylation. And those labs costs over $1,500 and it just wasn’t cost effective for my, my patients, you know, I can’t ask, I couldn’t even even get the words out. You need to, you know, pay a $1,500 plus to get that lab done. So what I ended up doing was I studied her book, I studied as much as I can online and I really understood how to clinically diagnose a certain types of variants that might be weaknesses and, and I basically tweaked it and I just, a lot of my, what I do is I do a lot of muscle testing as well, and I start to get to understand really which core methylation pathways do I need to understand and get these people to be able to change it by changing the supplementation, changing their lifestyle, things like that.

Dr. Bennett:                  So the technology didn’t catch up until a few years back when 23 and me 23 and me came out with a test. I think when they first came out, Joe, it was about $999 that was originally, it was very, very expensive even though that was a little well bet. But recently I’m a few years back, they changed it to $99 that was phenomenal because that’s when I thought, you know what? I’m now going to get back into what I’ve been talking about, what I’ve been, you know, sharing and, and you know, often with patients it’s hard to say, well this is what I think is going on and you can’t show them anything. You know what I mean? You can’t clearly show that, you know, Jeanette, these patterns are going on in you, um, with, and you have a laboratory test. So when 23, may 23 and me came out with a way that you can buy your raw data, that raw data, what it does is it looks at your genetic variance and all of these, these genetic fairs and there could be 100,000 of them and they give you a big, huge file from doing the 23andme.

Dr. Bennett:                  Now, 23 in me is really interesting because it looks at your ancestral background, where your people came from. I know exactly where my lineage came from and my mother was shocked that actually 27% of who I am is Japanese. And I actually thought it was 100% Korean and my mother’s told me and I fall, there’s only a D my genes go back. Many, many, you know, years of just being Korean. But you know what, we’re all mixed in some ways. So fascinating. And you’ll also even find out in 23, me, um, some of the major genetic diseases, but I’ll tell you what I’ve not yet, and I’ve done hundreds of these now with my patients. I have not yet found a person that had a very, very bad genetic disease. You know what I mean? So, uh, one that they, the 23andme shares. But what, what’s great about 23 me is they give you your own raw data and you don’t have to ever have to do this gene test ever again.

Dr. Bennett:                  You do it once. And um, and like I said, they teach you these, um, RS numbers are called the RS numbers mean that in the big file that you’ll see all these RS, if you kinda click on it and look at it and like, what are all these RS numbers? And RS stands for reference SNPs. On an S and V numbers. And, um, that’s where I take that raw data and then I put it through an actual platform. It’s actually software that I’ve got and then it starts spitting out. It’s brilliant, spitting out all of the relevant, relevant, um, uh, SNPs that you want to know about your methylation and much more, uh, methylation. You know, there’s a, there’s a really good handful that you need to know, but I go a little bit deeper. I go into other forms of genetic, um, variance that might be a problem.

Dr. Bennett:                  So yes, what we do. So you’re talking about the, obviously a couple of things. I want to come back to 23 and may a bit later, but tell us what first, what an SNP is. Yes. So an S and P stands for another way of calling it as a snip, you know, and you’ll listen. What’s your snip? What kind of snips do you have? It basically stands for single nucleotide polymorphisms. So what does polymorphism, I use the word polymorphisms in many, many different ways. Polymorphism means that you’ve got a genetic variant, a genetic variant, and a gene variant means like in your DNA, right? Every cell in your body has your genetic makeup, right in your cell. You’ve got your DNA in each cell. Well, that DNA looks like this. Okay. And if you can see it’s a double helix and then each, each part of the DNA had all of these different, and these are called nucleotides.

Dr. Bennett:                  But do you see how it’s all, there’s a purple and a green and the green is Agni. The purple is, I mean, and then there’s a red and a blue and that red is a side Azine. And the blue is a Guarani. Well, there’s actually a polymorphism or genetic variant. What’s going on is one is replacing another. So let’s say that, let’s look at, um, let’s look at MTHFR because MTHFR is, everyone wants to know about that, okay? Just to let you know, these snips occur a lot. You might have like 10 million snips, but that’s what makes you very unique, who you are, right? But these snips are, are passed down from your mother to your father. So let’s say that Joe, you’ve got one, mother’s got one to one snip and your father has one, and when you get one, let’s say for whatever reason you got one snip right that’s called heterozygous, alright?

Dr. Bennett:                  So you can have a heterozygous snip of your MTHFR heterozygous. That means you only got one copy from your mother. When you got to just one copy from let’s say your mother, then 30 to 40% of the time, that gene doesn’t work very well. So 70 to 60 to 70% it’s working really well, right? So that’s that. But if you get two copies, you get one from your mother and one from your father, that means it’s called homozygous. That’s when it gets a little bit more difficult for that enzyme to work, which means about 60 to 70% of them, it’s not working. All right, you do have it working 30 40% of time, but 60 70% of it doesn’t work. And that’s an important factor. That’s when you really want to know, because if you, you’ve got a lot of homozygous genes, then that means we’ve got to do something now.

Dr. Bennett:                  So that later on in the future, it’s not going to affect you. You’re not going to express some of these possibilities of what can happen. Right. That’s interesting. So, so if you have homozygous, you still have a small percent that’s still functioning, but you’re gonna need help to keep it rolling the way it should be going. Exactly. Do not believe that it’s just completely done and there’s no, there’s no use. That’s not correct. There are mutations, you know, you, we’ve sort of genetic mutations. Those are true mutations. A variant is not a mutation. Everyone is, some people call it mutations cause it’s an easy word, but I don’t call it very, those variants mutations. I called it imperfections. I’m an epigenetic genetic change, let’s say. You can say that you’ve got some gene variants and snips. You’ve got snips, right? Or a homozygous snip or a homozygous MTHFR.

Dr. Bennett:                  So when you talk about MTHFR though, there are actually now MTHFR, basically it’s the methylene tetrahydrofolate. That’s a reductase. That’s the actual enzyme I know. So who wants to remember those? All? I do. That’s too much. So when I talk to my patients, I just called them empty MTHFR gene. When I say gene, I’m talking about how the enzyme is working. So if you’ve got a homozygous or heterozygous, even with those two, the MTHFR gene, it’s important to know there’s two variants that are most well understood. The two value, your variants are called two snips, right? The two steps right here and takes you far and one becomes the a one to 1298 C and then there’s a C six seven seven T. now, what does this mean by the a and a C? Remember I told you earlier about the adenine and the cytosine.

Dr. Bennett:                  What this means that in this snip of a 1298 see, that means that the adenine has been replaced by the site. A Z. People don’t know this. The cytosine here in the, in the M C six seven 70 is has replaced the T. that’s the variant does that. I’ve seen those in my 23 and me reports. I’ve always wondered what the letters meant to before and after, so now I know. Now you know. Yeah, I know where I’m going to methylation. You’re getting a little bit more on your true genetics, but that’s important because some of these, remember I said that you have a lot of snips. We have a lot of these genetic merits, but what you want to do is you want to know which ones are the ones that you can change, which ones are the ones that really apply to us clinically, right?

Dr. Bennett:                  So let’s take a look at the a 12, 12, 98. See that one is really important. Neurological issues. You’ve heard of spinabifida, you know, different types of genes, right? Um, that are, that can, you can get, that’s the reason why you need to make sure when you’re pregnant, when a woman’s private, they need to take foliates, right? We talk about full lates. Um, some doctors will call it folic acid, but I want to make sure that people understand out there is a full, late is not folic acid, full lace or natural folates and which is B9. That’s in a vegetables and mainly green vegetables, nuts and seeds and things like that. But folic acid is synthetic. Joe synthetic many, many years ago when they found out that a lot of kids were being born, um, um, because they had low amounts of full lates, they started using full of gas and you’ve heard of what’s called fortified flour fortified cereal, right?

Dr. Bennett:                  Sure, yup. I highly recommend people not to eat, not to eat those fortified foods and fortified grains and fortified breads and flatter because those four to five, what that means is that the fortifying it with folic acid and folic acid because it’s synthetic, it actually needs to take a lot of uh, steps to get down to the MTHF. MTHFR is for that gene to work and what they’re found, the stays are now showing in the last few years is that you can actually, um, people can, depending on the individual, again, depending on your variant, your genetic variance and your snaps, you might not be able to process that well. You can store it and it may trigger some type of cellular mutations. Colon cancer and prostate cancer I believe are the two cancers that, that are common. Not common, excuse me, but can be linked to folic acid.

Dr. Bennett:                  It is, right? So it’s important that you need to eat, take Foleys, natural Foleys. And there are a lot of supplements still out there, even with this kind of information, the supplement companies have not picked up yet. And you’ll see on the label it’ll say folic acid. So make sure that you follow the, those companies that has full, late in early say natural folates super important. Okay. And then the a C six, six, seven, six, seven, seven, um, this one here, um, in the MTHFR, that second variant to me is one of the most important ones that you want to look at. And the reason is, is that it really applies to your heart. And, and because we’re clacking for strokes, for heart disease, right? For heart attacks, atherosclerosis, and about 45% of the population actually has that one heterozygous gene of that six, seven, 17.

Dr. Bennett:                  So that’s 45% of us, a lot of people, right? So then that means 30 to 40% of us, it’s not working very well. Okay? So, if that’s the case, no wonder our population in the U S it’s not just us, but I’m talking about, you know, all over, we have number one diseases, heart disease, isn’t that right? Heart disease. So that’s the reason why you really, it’s really important that we look at this MTHFR gene. Now, this MTHFR gene, it looks like this is a really easy member. I showed you earlier, the um, the, the four pathways that’s relating to methylation. Here it is, and it’s a little bit easier to understand. You’ve got the methoding cycle, you’ve got the full late cycle. And here’s the MTHFR right here. All right, so this is important and I’m like I said, it’s important for your heart. You know, I, I want to share with you a quick story if I may have.

Dr. Bennett:                  Tom. Tom came into me to see me, um, at 40 years old, at 40 years old. He was really, really concerned because, uh, he’s had his, he has a history of family, of heart attacks, heart disease. His grandfather, uh, he never met because his grandfather died at 45 years old. His father died at 45 years old, 46 years old as well. And his children, his young children has never even met his father. Meaning they didn’t even have a grandfather and he then their heart attacks or they’re dying. Oh, sorry. Yes. Both of them died of a heart attack. His older brother, older brother, five years older than him has already had minor heart attack. All right. He didn’t pass away. Thank goodness. And they’re doing everything that they can to mitigate that. So when my patient, John came to see me, it was 40 years old and he really didn’t want, I mean, he’s gone to all the doctors because all along growing up, he actually believed he was going to die at about 45 and at 40, he said, I’ve got to do something.

Dr. Bennett:                  Once his brother got one, he knew I’ve got to do something about it. So he came to see me and what we did, we did all kinds of blood tests and everything that would doctors do. But one of the things that I took a blood test was homocysteine. Homocysteine is not very regularly. Um, uh, you know, uh, looked at in any, you know, most doctors don’t even do it. A cardiovascular Dr. May or Hunter heart doctor might, but a lot of integrative doctors, we all do it, don’t we gel. And, and it’s really important for him to know why do we want the, the homocysteine? Homocysteine is actually the apart. Let me show you where homocysteine is. See the methionine here. Yup. See right here, right. This is, I know this says methylation cycle, but I want you to know it’s actually the methionine cycle.

Dr. Bennett:                  Whoever, I didn’t make this one up, I got this online, but whoever did this and they did a beautiful job. I see the homocysteine there is very close to the B6. So does it interact with um, some of our vitamins? Yes, absolutely. So homocysteine, why is it important? Because what they find is that it’s related to people who have got high levels of homocysteine. And that’s what I found in Tom. His, his was really high. Like I like the levels to be like 10, but it was at 15. Oh, is super high. Who knows how many years he’s been having this. Right? But it’s definitely one that’s prone. And people who’ve got it, they’re prone to plaquing of their arteries and when the plaques to it, and especially in the coronary arteries, if it’s too much than what it’s going to do, it’s going to block it cause inflammation.

Dr. Bennett:                  And then you get what’s called an myocardial infarction, which is heart attack, right? So the blood flow, that’s when you let that blood flow to the tissues, then you’re going to be getting, um, a heart disease, heart attack. So it’s super important that we all get our homocysteines check. If you don’t want to do the 23 and needs, you know, and get all that done, then at least do the, get the homocysteine, ask your doctor. It only costs like 60 to $70. And, and what we did for Tom is that knowing that that was really high, I wanted to make sure, make sure this cycle was working, it was working right so that we can make sure that the homocysteine is moving and getting away. Remember, homocysteine becomes methionine. So keeps on recirculating breaking it down, making it recycling. And this folate, MTHFR is super important for this whole cycle to occur.

Dr. Bennett:                  Okay? So it’s kind of like you’re in a factory and you’ve got people working for you and you’ve got to get the, everyone is got to be on their game. You can’t have someone backing up slowing down. Cause if they did, everything’s in a backup before it or everything’s not going to get enough down, down low. Right? So it’s important that you get all that moving. Anyway. What I did was, uh, for Tom, we got all sorts of nutrients that are necessary. Uh, trimethylglycine B six B12, a special kind of B12, a full lates of course five MTHF. So that finding, teachF our enzyme, actually the precursor of that into five MTH F which is a special kind of five methyltetrahydrofolic. So that special kind of Foley, if you’ve got a problem with that actual MTHFR double, let’s say it’s a double, um, homozygous homozygous mean double a Lele to double, then you’ve got to be taking some of that.

Dr. Bennett:                  You really, everyone should be on, not everyone should be on it every single day because I’ve found people, they take way too many. You know, I say start with one, one, just one milligram of five MTHF and do it every other every third day. And I start that every third day because you can get what’s called too fast of a methylation where it goes way too quickly. And if you have way too much, then you’re gonna have other problems down the line. So let’s say, like I said, um, I use other kinds of B six, you saw that B six that was important for moving that homocysteine. Zinc is important. Magnesium, Oh, magnesium is super important for many, many different pathways throughout our body. But for a methylation, you know, when I think about, about, you know, any kind of anyone who comes to see me, you know, I got to look at really what is what you’ve got to look at how your, you come into, um, looking at how your body is in the continuum of health.

Dr. Bennett:                  Where are you located? So when I say continue to health, that means you, there’s like a line of from disease to help and you might be born with a really good area. You know, you’ve, you’ve started out healthy, you started out young and energize, you’ve got brains, sharp memories, amazing. You get great sleep, you have good sex, I mean everything. And then you know, you start to slip. As we get older, it gets closer and closer and closer to this direction. But that doesn’t need to really be, I mean, I really think that as you age, it should be, you should do it with more energy. Continuing and sparking up your mitochondria is making sure that you’re eating well, doing all the right things. And by doing that, there’s three ways this disease and health that I show you here. It only depends on three things.

Dr. Bennett:                  Joe. First is your Nutrogenomix, which is your, how you eat, what you take in your supplementation, your nutrition, all right? It’s a study of what’s going on into your body, what you’re eating and the nutrients and how that’s related. Remember I said that I had to give a B12 B six five MTHF to Tom, right? That’s the neutral genomic portion. Then I looked at his for Tom, I looked at his epigenetics, his second part, which is his environment. He was not, he was very much a, you worked out a lot, but he flew a lot too because he did a lot of consultations. So he’s always in the air. And you know what, when you’re flying a lot, you get so much radiation in your body. It’s ridiculous. You can need tons of antioxidants. You need tons. I mean, not just that. Let’s talk about the sleep app.

Dr. Bennett:                  It’s on all of this, right? That’s all related. And then the environment things that he was getting, not just radiation, but he was eating for Lee of course, and drink a lot, and he was sleeping in places like these Airbnbs. You gotta be careful. You get these know moldy homes and apartments and that’s not good. So that’s all related because that will stress your body out. That’s what stress your methylation out. And then that will stress who you’re going to become. And of course cause you more disease. And then the third leg is what we’re talking about today. The third leg are actually your, your DNA, your genes, your methylation processes. You’ve got to look at all three. If you look at all three, that’s going to either give you health or it’s going to give you disease and it’s totally up to you. You can make, it is, it’s, you know, I talk about a lot in my seven day LG makeover. You know, the first, first two. I talk a lot about it, the nutrition, the, the um, how you clean up your environment. That one is in my seven day ads you make over book. You know, in my second book, the mighty Mito Joe, I don’t think you know, maybe you do, but last year when we did the pain summit, um, I didn’t have my buddy might a book out, right?

Dr. Joe Tatta:                Number one best selling book is new since then.

Dr. Bennett:                  Yeah, that’s right. The mighty mighty book. It’s awesome. It’s, it’s, I go into everything about your mitochondria health and how it’s related in fact to methylation. I told you earlier what, uh, why the Mito Mito Mito mitochondria is so important for methylation, but it’s important for every disease. Every disease in your body is related to your mitochondria health and how well every cell is going to function optimally. You need energy. That’s what we’re, the Chondra is a Fort. You need energy. It’s important for antioxidant production as well. And um, I go into that so that you can think faster, you have more energy, you can build your muscles, and then of course you can live pain free. You know, that’s really what we want. We want to live a pain-free, healthy lifestyle. Don’t wait.

Dr. Joe Tatta:                Excellent. So, and you know, obviously all these methylation pathways are happening in every cell as well as our mitochondria as well.

Dr. Bennett:                  Oh gosh. Methylation. You know what there is, when you think about methylation, it does because there are specific, um, uh, how do I say specific enzymes in the mitochondria that’s specifically for the mitochondria. You know what I mean? So what I mean by that is there’s one called the end Duff, and that’s super important for a niacin and that’s why you need niacin and Coke. UTEC Coke. You can, because this is my favorite. This is my, I love Coke. This might, it might accuse my favorite cookie because cookie tin is very hard to deliver into the mitochondria. And if you can’t get it in, then you’re going to fail that, that, that first complex in the mitochondria for the electron transport chain so that you can exchange these hydrogen atoms. I know I’m going into a deep, but what it does is you need a special kind of of um, genetic processes. So it’s super important that you understand you need your genes to be as healthy as you can.

Dr. Joe Tatta:                Great. So lots of, lots of great information on this interview. Dr Susanne, thank you so much. And obviously I love the show and tell because no one’s done show and tell on this summit. So I think it’s really important that, you know, people get to see you speak. Obviously you’re a wealth of information, but plus there’s, you know, getting to, you know, people learn by visual. They learned by hearing, they learn by, um, you know, touching and seeing and feeling. So it’s a, it’s a great luxury gave. So I want to thank you. And he said, everyone know how they can hear about, you know, how they can learn more about you, where you’re located, what you do.

Dr. Bennett:                  Sure. Sure. You know what, I do want to make sure that everyone understands. I did go briefly into how you need to take look at your, um, your environment and all that. But it’s, you know, I also believe that it’s super important that you deal with like your stresses in your life and it makes everyone, you know, right before you and I in fact started this, um, interview you helped me with doing deep breaths, right? And helping me release stress. And I’m doing gel belly breaths and things like that. And, and I mentioned about how also you make sure that lifestyle has to do with your sleep and, and, um, and you know, you gotta stop doing all the things that we’re not supposed to do. Of course, smoking and drinking and, and doing all these recreational drugs because, you know, it doesn’t, it doesn’t make sense if you’re really pushing your body to that level of being really, uh, stressing out and doing all these vices, things that, and eating the wrong foods because, and then you think, Oh, I can take my methylation supplements and I’ll be just fine.

Dr. Bennett:                  You know, that’s just not gonna work. So you want to clean up your nutrition, clean up your body and make sure that remember the full lights, you just don’t want to, you don’t, the folic acid you don’t want to do organic is always the best way. Clean up your gut, look at your gut permeability if you’ve got that, because that will also contribute to methylation issues. Um, you know, so much. Anyway, all of that stuff you can find out on my website, dr susanne.com. You can also, I mean my, I have a free, I have a free gift for you guys. Awesome free gift. Where’s that free gift go here it is. So what I’ve made up is that you could, you can get my guide, it’s like a report. Here’s my methylation one-on-one report and what you get to get you. You’re also going to get this here quick start guide and that quick start guide is really important because I’m going to teach you how to do your whole 23andme, how do where to go, where to get it, how to download your raw data and then how, where do you go from there?

Dr. Bennett:                  Because a lot of people have the raw data but they don’t know what to do and I give you the by step process to do that and that’s in your free gift.

Dr. Joe Tatta:                Excellent. So make sure you check out Dr. Susanne’s free gift. You obviously you’re going to get some great information there if you have a chance. If you haven’t done it already, do 23 meats super easy. It’s super fast and you’ll be able to take that either to Dr. Susanne directly or you’ll be able to take it to a practitioner near you who hopefully can start to help you unravel any genetic snips and methylation problems that you may have. I want to thank Dr Susanne for being here on season two. Um, you know, dr Susanne is the real deal. I know her from for many years now. We’ve been to seminars and conferences and both of us really walk our walk. We weren’t doing breathing before this and we didn’t set an intention for a great interview. We both eat almost a hundred percent organic whenever we can. So, um, you know, we’re really giving you some powerful tools to live a healthy and pain free life, but to help us out and obviously help Dr. Susanne now make sure you hit the share button so you can share this video on Facebook and on Twitter. So you’ll spread the message to all your friends and family and you’ll help us spread the message of the entire healing pain summit. I want to thank Dr. Susanne again and we’ll see you next on the next interview.

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